Detalle del Docente 2016-12-06T16:49:11+00:00

Maisonnave Vicens Thievent, Jacqueline Rosa

DATOS PERSONALES Y ACADÉMICOS

Grado y Servicio

Grado 5 / Facultad de Veterinaria / Instituto de Patobiología Veterinaria

Contacto

Email: jacmaiso@gmail.com / Teléfono: 26281303

Área disciplinar

Agraria

Disciplina / Subdisciplina

Salud animal / Inmunología / Virología / Medicina Regenerativa Veterinaria

Mayor nivel académico

Doctorado, University of California at Davis, Estados Unidos (año 1989)

Link a web personal

www//fvet.edu.uy/inmuno

Link a CVUY

http://www.anii.org.uy/cvuy/enlinea.php?sub=sel_datos_grales

Pertenece al SNI

No pertenece

Pertenece al PEDECIBA

No pertenece

DATOS DEL PROYECTO DE DEDICACIÓN TOTAL

Título del Plan de Actividades

He formado RRHH en la línea inicial de investigación de mi DT, quienes continúan con ella. En 2007 comencé en Medicina Regenerativa Veterinaria, en Equinos Deportivos y Caninos, con dicha línea se formó un Veterinario y se están formando en PPGFV 1 doctorando, 1 maestrando, 6 estudiantes de grado.

Palabras clave

allogenic, MSC-AT, non union, canine

Resumen Publicable

Allogeneic stem cell transplantation for bone regeneration of a nonunion defect in a canine

Kevin Yaneselli, Andrea Filomeno, Gabriel Semiglia, Carolina Arce, Analía Rial, Natalia Muñoz, María Moreno, Kent Erickson,
Jacqueline Maisonnave

Abstract: Nonunion bone defects occur frequently with local pain, functional limitations, muscular atrophy, and fistulas due to osteomyelitis. The application of mesenchymal stem cells (MSCs) could improve regeneration of bone following bone defects. The objective of the present study was to evaluate the treatment of a nonunion defect due to chronic osteomyelitis in a greyhound female dog with allogeneic adipose tissue-derived mesenchymal stem cells (AT-MSCs). The implanted cells were adherent to plastic, were of fibroblast type, and expressed the canine stem cell markers CD90low, CD44high, and CD45-. Cell therapy consisted of five percutaneous weekly injections of 2 × 106 allogeneic AT-MSCs into the bone defect (total of 10 × 106 AT-MSCs). The patient was evaluated clinically and radiologically for up to 1 year. The results were clinical improvement, a light lameness score of 1 at week 16, return to use of its forearm, no pain, and increased muscular mass. No signs of osteomyelitis were observed radiologically and clinically there were no fistulas. There was no evidence of local or systemic adverse reactions caused by the alloimplants. The clinical relevance of the cell therapy contributing to repair of bone defects in small animals is a very promising future alternative. These results may have an important impact in new regenerative treatments for animal and human orthopedics.

Grado y Fecha de Ingreso al RDT

Grado 3 / Desde: 1998-01-02

Programa: Científico Proveniente del Exterior

El cargo NO se enmarca en este programa

Participa de Grupo Autoidentificado

Grupos: GRUPO INVEST STEM CSIC num 881142
grupo invest UDELAR stem cells en veterinaria

Observaciones

en sabático – 10/03-25/05/13 y 09/03-05/07/15

DOCUMENTACIÓN ADJUNTA

Curriculum Vitae

Descargar CV

Último informe de renovación

Aún no se ha cargado el último informe de renovación.

Producción Académica

Documento 1: Descargar Produccion Académica 1
Documento 2: Descargar Produccion Académica 2
Documento 3: Descargar Produccion Académica 3